Abstract: Recent Knowledge on Borderline Resectable Pancreatic CancerWeidong MA, Jihui HAOCorrespondence to: MAWeidong, E-mail: maxfree@medmail.com.cnDepartment of Pancreatic Cancer, Tianjin Medical University Cancer Institute and Hopital, Tianjin 300060, ChinaAbstract With the development and application of new pancreatic imaging and surgical techniques, there is a new sub-type ofpancreatic cancer called "borderline resectable" cancer that has been distinguished from "resectable" and "locally advanced" pancreaticcancer by surgeons. This sub-type includes tumors that invade the hepatic artery, portal vein, or superior mesenteric artery or vein. Theresection and re-construction of the involved vessel is possible in these cases. The resectable rate of pancreatic cancer would be signifi-cantly elevated by performing radical surgery for "borderline resectable" pancreatic cancer. With the present surgical techniques, posi-tive margin is very common in "borderline resectable" tumors, a fact that surely impacts patient prognosis. Consequently, it would bebeneficial to promote pre-operative staging of "borderline resectable" pancreatic cancer and combine neo-adjuvant therapy with surgeryto achieve R0 resection and improve the prognosis of such patients.Keywords Pancreatic neoplasm; Borderline resectable; Neo-adjuvant therapy